Vitamin d receptor (VDR) and folate metabolism genetic polymorphisms

Vitamin d receptors are found in most of the body’s cells. Some people have “VDR genetic polymorphisms”. You might have a polymorphism which allows you to have superior vitamin d metabolism or you might on the contrary have a faulty VDR polymorphism. The negative effects of faulty polymorphisms can often be overcome with high dose or very high dose supplementation.

Vitamin d and disease

Vitamin d deficiency is implicated in every chronic disease. So the first step in finding out whether you have a defective VDR polymorphism and whether it’s that which is responsible or partly responsible for your disease is to get your serum vitamin d level tested. I recommend aiming to reach 50 ng/ml (125 nmol/L) which is highly sufficient. If that does not lead to a great improvement in your symptoms, a VDR polymorphism may be suspected. Note that I am a simple health nut and not a doctor or a PHD and the subject of genetics is above my pay grade so my recommendations should be seen in that light. High dose or very high dose vitamin d supplementation can cause hypercalcemia with some nasty symptoms.

Could your vitamin d deficiency really be a genetic polymorphism?

Can you be tested for genetic polymorphisms? Yes. There are genetic testing companies. 23andMe for example.

The Coimbra protocol

The Brazilian professor, Dr. Coimbra gives an average of 1,000 i.u.’s of vitamin d per kilo weight of the patient to reverse autoimmune diseases. But this should not be tried at home!

There is a strict protocol and frequent testing and this has to be done under the supervision of a Coimbra trained physician.

Could your vitamin d deficiency or suspected polymorphism be caused by defective bile metabolism?

I personally believe that vitamin a metabolism may be much more of a factor than VDR polymorphisms. For example Dr. Coimbra sometimes gives huge doses of vitamin d for Multiple Sclerosis patients. Basically he keeps on increasing the dose until it works. Way more than 70,000 i.u.’s sometimes and he claims a 95% success rate. But from my own research on the pubmed database I noticed that MS patients have defective bile metabolism. You need some fat in your food to stimulate bile production and transform beta carotene into retinol, the animal form of vitamin a. Vitamin d receptors are retinoids! So could it be defective bile production which is the real culprit? Supplementing with super high dose vitamin d may work but it’s acting like a drug.

Efficient bile production and optimum transformation of carotenes into retinol might be just as important as adequate serum levels of vitamin d. I think inadequate bile production is an easy fix. The Seignalet diet makes all of the body’s cells function properly and the liver and gall bladder function are much improved on the diet. But I think we can get the gall bladder fixed much quicker though and my supercharged version of the Seignalet diet will achieve this. How?

With high dose vitamin c and supplementing with 3/4 of a teaspoonful of taurine every day. (See my healthiest breakfast ever). Bile is made from taurine and cholesterol. Vitamin c aids in the transformation of cholesterol into bile acids.

My speculative conclusion: Take 10.000 i.u.s of vitamin d per day with some vitamin k2 and magnesium chloride hydroxate.