Posted by Disclaimer: Glucocorticosteroids may be useful in emergency situations like acute brain trauma.
The featured image comes from a Wikipedia article on Cushing syndrome which is caused by glucocorticosteroid therapy. “.. 3 months after therapy with inhaled fluticasone propionate and antidepressants..” So I assume that the lady had asthma. Dr. Seignalet called asthma “an elimination disease”. Out of 85 asthmatic patients treated with his diet, 80 had 100% remissions, 3 had 50% improvements and there were 2 failures. (He did not give the patients vitamin d supplements).
Here is a study showing that asthmatics have vitamin d deficiency:
Results: Out of 98 included children, 25-OH vitamin D levels were deficient and insufficient in 41 (41.8%) and 34 (34.7%) children, respectively. Only 23 (23.5%) had sufficient 25-OH vitamin D levels. A significant correlation was found between severity of asthma symptoms and 25-OH vitamin D deficiency.
…deficient (<20 ng/ml), insufficient (20–29 ng/ml), or sufficient (>29 ng/ml)..
Conclusion: 25-OH vitamin D deficiency is highly prevalent in Jordanian children with bronchial asthma and correlates significantly with asthma severity.
Vitamin D deficiency in children with bronchial asthma in southern Jordan: a cross-sectional study
Al-Zayadneh
Note: I’m willing to bet that if the kids were supplemented with vitamin d until their serum level was at least 50ng/ml their asthma would be cured. .
Vitamin d = the right switch
Steroid drugs = the wrong switch
Steroid drugs are not only the wrong switch, they turn off vitamin d, the right switch.
…The mechanisms by which glucocorticoids (GC) inhibit some actions of vitamin D [1,25-(OH)2D3] are not well understood, but there is growing evidence that GC alter vitamin D receptor (VDR) number….
…Since the half-life of VDR mRNA was not significantly modified by dexamethasone, glucocorticoids appear to decrease VDR mRNA by inhibiting VDR gene transcription or by affecting the processing of VDR mRNA…..
Glucocorticoids decrease vitamin D receptor number and gene expression in human osteosarcoma cells. Godschalk et al 1992
Long story short: steroid drugs fuck you up. Vitamin d at the correct dose is much more effective at reducing inflammation and does this in a totally natural way. There are no adverse effects at the normal physiological (ie. natural) dose achieved by daily exposure to the sun in summer, use of a tanning bed or supplementation with 10,000 I.u. of vitamin d3. What’s more, apart from fighting inflammation there are myriad other health benefits from vitamin d.
….Conclusions: Our study failed to show a beneficial effect of oral corticosteroids on allergen-specific immunotherapy. We observed that the combined administration of a corticosteroid drug and allergen extract suppressed the early clinical and immunological effects of Specific Immunotherapy and that vitamin D(3) prevented this ‘adverse’ influence of steroids…. (Chris’s emphasis)
. Majak et al 2009
.
The pharma fuck-you-up cascade
By the way, it’s been obvious from the start to anyone with half a brain that the “covid pandemic” was a depopulation agenda. Are they killing us, “the useless class” only because we are no longer needed? Perhaps there is also an element of getting rid of us before we wake up and realise that their filthy drugs are not keeping us healthy but quite the opposite.
Steroids, the second step in the cascade
Steroids are the second step in the pharma fuck-you-up cascade, used when the first step, non steroidal anti inflammatories (NSAID’s) like aspirin (used by Hippocrates in the form of willow bark two and a half thousand years ago) and its dozens of me-too variations no longer have an effect. The third step, when the steroid drugs no longer work is immune suppressant drugs to give you pharma induced AIDS. Good luck if you have a dormant toxoplasma gondi parasite infection – spread by cats – in your brain and kept in check by your immune system, you will end up with a brain tumour like John McCain.
Vitamin d cell receptor and ligand versus Steroid drug cell receptor and ligand
In the cell nucleus of all living creatures there are “nuclear cell receptors”. In humans, certain cell receptors are present or absent in cells of all the different tissue types. A receptor is activated by a specific substance called a “ligand”. For example the vitamin d receptor is activated by its ligand, the active form of vitamin d, calcitriol. The retinoic acid receptor is activated by its ligand, vitamin a (retinol). (Not to be confused with the retinoid x receptor which we will look at further on). In humans there are about 14 nuclear cell receptors plus their subtypes. Each receptor or subtype is activated by a specific ligand. For some receptors, the specific ligand has not yet been identified. These are called “orphan receptors”.
What happens when a receptor is activated by its ligand? It activates “gene expression” of a specific gene by “transcribing” the instructions contained in that gene’s double stranded DNA, (Deoxyribonucleic acid) using an enzyme, RNA polymerase, into single stranded “messenger” ribonucleic acid, mRNA. The mRNA then exits the cell’s nucleus via pores in the nucleus into the cell’s outer portion, the cytoplasm, where the instructions are read by a ribosome to make a string of amino acids to form a particular peptide (protein). (Note: this is a simplification. For example, vitamin d receptors are found in all parts of the cell)
Wiki commons: By Boumphreyfr vector conversion by Glrx
How use of corticosteroids to treat inflammation became entrenched medical dogma
In 1929 at the Mayo clinic in the US, a rheumatologist named Hench was treating a patient with rheumatoid arthritis whose symptoms disappeared after developing acute jaundice. The same year, Kendall, a biochemist started analysing bovine adrenal glands. He discovered that they produce 6 hormones. He named them A through F. Four of them had physiological activities. They are: aldosterone (a mineralocorticoid), compound E: cortisol (a glucocorticoid), and the sex hormones androgens and estrogen. In 1941 the Merck chemist Sarrett worked for 3 months in Kendall’s lab. He returned to Merck and worked on synthesizing “compound E”. In 1946 he published the 37 step process for synthesizing cortisone starting with desoxycholic acid.
“..Sixty years after Kendall, Hench, and Reichstein were awarded the Nobel Prize for their groundbreaking research of adrenal steroids, cortisone and other structurally related synthetic analogs remain among the most widely prescribed medications..”
Information found in: Discovery of the Wonder Drug: From Cows to Cortisone
Here are a few of the many glucocorticosteroid drugs (synthetic cortisol): beclomethasone, betamethasone, budesonide, cortisone, dexamethasone, hydrocortisone, beclomethasone, , cortisone, methylprednisolone, prednisolone.
……..
“..Glucocorticoids (GCs) are a group of drugs structurally and pharmacologically similar to the endogenous hormone cortisol with various functions like anti-inflammatory, immunosuppressive, anti-proliferative, and vaso-constrictive effects..”
….Corticosteroids are hormone mediators produced by the cortex of adrenal glands that further categorize into glucocorticoids, mineralocorticoids, and androgenic sex hormones…
…Corticosteroids constitute a double-edged sword – significant benefit with a low incidence of adverse effects can be expected if used in proper dosage and for a limited duration; however, wrong dose and/or duration and unmindful withdrawal after prolonged administration can have catastrophic effects…. (Chris’s emphasis)
..The development of cushingoid features (redistribution of body fat with truncal obesity, buffalo hump, and moon face) and weight gain are dose and duration-dependent and can develop early. Cushingoid features showed a linear increase in frequency with dosing. Glucocorticoid therapy is the most common cause of Cushing syndrome. The clinical presentation in the pediatric population is similar to that in adults and includes truncal obesity, skin changes, and hypertension. In children, growth deceleration is also a feature…
..Cardiovascular Adverse Effects
…Mineralocorticoid effects, especially as seen with cortisol and cortisone, can lead to fluid retention, edema, weight gain, hypertension, and arrhythmias by increasing renal excretion of potassium, calcium, and phosphate. Hypertension usually occurs with higher doses only. Long-term use of medium-high dose glucocorticoids has implications in premature atherosclerosis in a dose-dependent pattern..
Corticosteroid Adverse Effects
Note: The above is from a US National Institutes for Health (NIH) publication which is copyright free, allowing me to use lengthy quotes.
…….
…Glucocorticoids influence about 20% of the expressed human genome, and their effects spare almost no organs or tissues. For many years we thought that the numerous actions of glucocorticoids were mediated by a single receptor molecule: the classic glucocorticoid receptor (GR) isoform alpha, a complex, multifunctional domain protein, operating as a ligand-dependent transcription factor. The GR gene, however, encodes two 3′ splicing variants, GRalpha and GRbeta, from alternative use of two distinct terminal exons (9alpha and 9beta), and each variant mRNA is translated from at least eight initiation sites into multiple GRalpha and possibly GRbeta isoforms, amounting to a minimum of 16 GR monomers and 256 different homo- or heterodimers. The translational GRalpha isoforms may be produced variably in target tissues, have varying intrinsic transcriptional activities, and influence different complements of glucocorticoid-responsive genes. It is likely that expression and functional differences might also be present between the putative GRbeta translational isoforms. The presence of multiple GR monomers and dimers in different quantities with quantitatively and qualitatively different transcriptional activities suggests that the glucocorticoid signaling system is highly stochastic….” (meaning of stochastic: random)
Intracellular glucocorticoid signaling: a formerly simple system turns stochastic
Translation: “We have no idea what corticosteroid drugs are doing to your body!” So the drugs are stimulating the production of random proteins in about 20% of your body’s cells. In other words, filling your cells with junk.
Glossary
Nuclear receptors
….. nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. In response, these receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism.
Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes; hence these receptors are classified as transcription factors…….. …..ligand binding to a nuclear receptor results in a conformational change in the receptor, which, in turn, activates the receptor, resulting in up- or down-regulation of gene expression…...The agonistic effects of endogenous hormones can also be mimicked by certain synthetic ligands, for example, the glucocorticoid receptor anti-inflammatory drug dexamethasone…
….The regulation of gene expression by nuclear receptors generally only happens when a ligand—a molecule that affects the receptor’s behavior—is present….
…a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose…..
Gene expression
“…Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA…. ……”
Gene transcription by Prabarna Ganguly, Ph.D. Science Writer/Editor, US National Institutes for Health
….Transcription. Transcription is like translating a book from one language to another. While DNA is more stable of a molecule, RNA is the more universal biological language….
…Transcription….. is the process of making an RNA copy of a gene’s DNA sequence. This copy, called messenger RNA (mRNA), carries the gene’s protein information encoded in DNA. In humans and other complex organisms, mRNA moves from the cell nucleus to the cell cytoplasm (watery interior), where it is used for synthesizing the encoded protein…
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